Best Bets for NCAA Basketball Picks Against the Spread for Saturday, February 22
Published 7:22 pm Friday, February 21, 2025
The college basketball lineup on Saturday is not one to miss. Our computer model has suggested picks against the spread for 10 games, including the Iowa State Cyclones taking on the Houston Cougars at Fertitta Center.
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Today’s NCAA Men’s Basketball Picks ATS
ATS Pick: Iowa State +12.5 vs. Houston
- Matchup: Iowa State Cyclones at Houston Cougars
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Houston by 6.7 points (Bet now on BetMGM)
- Spread: Houston (-12.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Saint Francis (PA) +1.5 vs. Fairleigh Dickinson
- Matchup: Fairleigh Dickinson Knights at Saint Francis (PA) Red Flash
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Saint Francis (PA) by 3 points (Bet now on BetMGM)
- Spread: Fairleigh Dickinson (-1.5)
- TV Channel: NEC Front Row
ATS Pick: Cal Baptist +9.5 vs. Grand Canyon
- Matchup: Cal Baptist Lancers at Grand Canyon Antelopes
- Time: 8 p.m. ET
- Date: February 22
- Computer Projection: Grand Canyon by 5.6 points (Bet now on BetMGM)
- Spread: Grand Canyon (-9.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Ole Miss +1.5 vs. Vanderbilt
- Matchup: Ole Miss Rebels at Vanderbilt Commodores
- Time: 3:30 p.m. ET
- Date: February 22
- Computer Projection: Ole Miss by 2.2 points (Bet now on BetMGM)
- Spread: Vanderbilt (-1.5)
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Kentucky +9.5 vs. Alabama
- Matchup: Kentucky Wildcats at Alabama Crimson Tide
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Alabama by 5.9 points (Bet now on BetMGM)
- Spread: Alabama (-9.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Bet on this or any men’s college basketball matchup at BetMGM.
ATS Pick: McNeese -10.5 vs. Texas A&M-CC
- Matchup: Texas A&M-CC Islanders at McNeese Cowboys
- Time: 5 p.m. ET
- Date: February 22
- Computer Projection: McNeese by 13.9 points (Bet now on BetMGM)
- Spread: McNeese (-10.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Little Rock -10.5 vs. Western Illinois
- Matchup: Western Illinois Leathernecks at Little Rock Trojans
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: Little Rock by 13.9 points (Bet now on BetMGM)
- Spread: Little Rock (-10.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: West Virginia +11.5 vs. Texas Tech
- Matchup: West Virginia Mountaineers at Texas Tech Red Raiders
- Time: 1 p.m. ET
- Date: February 22
- Computer Projection: Texas Tech by 8.1 points (Bet now on BetMGM)
- Spread: Texas Tech (-11.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Rhode Island +6.5 vs. Saint Louis
- Matchup: Rhode Island Rams at Saint Louis Billikens
- Time: 2:30 p.m. ET
- Date: February 22
- Computer Projection: Saint Louis by 3.3 points (Bet now on BetMGM)
- Spread: Saint Louis (-6.5)
- TV Channel: USA
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Campbell +1.5 vs. Towson
- Matchup: Towson Tigers at Campbell Fighting Camels
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Campbell by 1.5 points (Bet now on BetMGM)
- Spread: Towson (-1.5)
- TV Channel: FloCollege
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